ZEPBOUND is an injectable prescription medicine used with a reduced-calorie diet and increased physical activity to help adults with:
• obesity, or some adults with overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off.
• moderate to severe obstructive sleep apnea (OSA) and obesity to improve their OSA.

ZEPBOUND contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines.

It is not known if ZEPBOUND is safe and effective for use in children.

• Read the Instructions for Use that comes with ZEPBOUND.
• Use ZEPBOUND exactly as your healthcare provider tells you to.
• Your healthcare provider should show you how to prepare to inject your dose of ZEPBOUND before injecting the first time.
• A caregiver may give you ZEPBOUND injections or you may self-inject if a healthcare provider determines that it is appropriate.
• Self-injection is not recommended for people who are visually impaired.
• Use ZEPBOUND with a reduced-calorie diet and increased physical activity.
• If using ZEPBOUND vials, always use a new syringe and needle for each injection.
• Inject ZEPBOUND under the skin (subcutaneously) of your stomach (abdomen), thigh, or another person should inject in the back of the upper arm. Do not inject ZEPBOUND into a muscle (intramuscularly) or vein (intravenously).
• Use ZEPBOUND 1 time each week, at any time of the day.
• You may change the day of the week you use ZEPBOUND as long as the time between the 2 doses is at least 3 days (72 hours).
• If you miss a dose of ZEPBOUND, take the missed dose as soon as possible within 4 days (96 hours) after the missed dose. If more than 4 days have passed, skip the missed dose and take your next dose on the regularly scheduled day. Do not take 2 doses of ZEPBOUND within 3 days (72 hours) of each other.
• ZEPBOUND may be taken with or without food.
• Change (rotate) your injection site with each weekly injection. You may use the same area of your body but be sure to choose a different injection site in that area. Do not use the same site for each injection.
• If you take too much ZEPBOUND, call your healthcare provider or Poison Help line at 1-800-222-1222 or go to the nearest hospital emergency room right away.

ZEPBOUND may cause serious side effects, including:

• See “What is the most important information I should know about ZEPBOUND?”
• severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use ZEPBOUND. Tell your healthcare provider if you have stomach problems that are severe or will not go away.
• dehydration leading to kidney problems. Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration.
• gallbladder problems. Gallbladder problems have happened in some people who use ZEPBOUND. Tell your healthcare provider right away if you get symptoms of gallbladder problems which may include:
◦ pain in your upper stomach (abdomen)
◦ fever
◦ yellowing of skin or eyes (jaundice)
◦ clay-colored stools
• inflammation of your pancreas (pancreatitis). Stop using ZEPBOUND and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back.
• serious allergic reactions. Stop using ZEPBOUND and get medical help right away if you have any symptoms of a serious allergic reaction including:
◦ swelling of your face, lips, tongue or throat
◦ problems breathing or swallowing
◦ severe rash or itching
◦ fainting or feeling dizzy
◦ very rapid heartbeat
• low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use ZEPBOUND with medicines that can cause low blood sugar, such as an insulin or sulfonylurea.
Signs and symptoms of low blood sugar may include:
◦ dizziness or light-headedness
◦ blurred vision
◦ anxiety, irritability, or mood changes
◦ sweating
◦ slurred speech
◦ hunger
◦ confusion or drowsiness
◦ shakiness
◦ weakness
◦ headache
◦ fast heartbeat
◦ feeling jittery
• changes in vision in patients with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with ZEPBOUND.
• depression or thoughts of suicide. You should pay attention to any changes in your mood, behaviors, feelings, or thoughts. Call your healthcare provider right away if you have any changes to your mental health that are new, worse, or worry you.
• food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). ZEPBOUND may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking ZEPBOUND before you are scheduled to have surgery or other procedures.

The most common side effects of ZEPBOUND include:
• nausea
• stomach (abdominal) pain
• allergic reactions
• diarrhea
• indigestion
• belching
• vomiting
• injection site reactions
• hair loss
• constipation
• feeling tired
• heartburn

• Store ZEPBOUND in the original carton to protect it from light.
• Do not freeze ZEPBOUND. Do not use ZEPBOUND if frozen.
• Store single-dose pen and single-dose vial in the refrigerator between 36°F to 46°F (2°C to 8°C). If needed, each single-dose pen or single-dose vial can be stored at room temperature up to 86°F (30°C) for up to 21 days. If single-dose pen or single-dose vial is stored at room temperature, it should not be returned to the refrigerator. Throw away single-dose pen or single-dose vial if not used within 21 days after removing from the refrigerator.
• Store multi-dose vial or single-patient-use KwikPen in the refrigerator between 36°F to 46°F (2°C to 8°C) or at room temperature [up to 86°F (30°C)]. Throw away the multi-dose vial or single-patient-use KwikPen after a total of 30 days at room temperature, 30 days after first use, or after taking 4 weekly doses, even if it still has medicine in it.

Keep ZEPBOUND and all medicines out of the reach of children.\

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use ZEPBOUND for a condition for which it was not prescribed. Do not give ZEPBOUND to other people, even if they have the same condition you have. It may harm them. You can ask your pharmacist or healthcare provider for information about ZEPBOUND that is written for health professionals.

Active ingredient: tirzepatide

Inactive ingredients: sodium chloride, sodium phosphate dibasic heptahydrate, and water for injection. Benzyl alcohol, glycerin, and phenol are also inactive ingredients in the multi-dose vial and single-patient-use KwikPen. Hydrochloric acid solution and/or sodium hydroxide solution may have been added to adjust the pH.